Many viral diseases can be fought by immune system-augmented Vitamin D - Sunil Aug 2024

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Unlocking insights: Navigating COVID-19 challenges and Emulating future pandemic Resilience strategies with strengthening natural immunity

Heliyon 2024 Jul 17;10(15):e34691. doi: 10.1016/j.heliyon.2024.e34691
Sunil J. Wimalawansa

Table of Contents

Those with more vaccinations were more likely to get COVID infection

Death rates in countries with more >70% vaccinated were 100X higher than counries with <15% vaccinated

Cost of material to prevent a COVID death

The original COVID-19 vaccines, developed against SARS-CoV-2, initially mitigated hospitaliza­tions. Bivalent vaccine boosters were used widely during 2022-23, but the outbreaks persisted. Despite this, hospitalizations, mortality, and outbreaks involving dominant mutants like Alpha and Delta increased during winters when the population’s vitamin D levels were at their lowest. Notably, 75 % of human immune cell/system functions, including post-vaccination adaptive immunity, rely on adequate circulatory vitamin D levels. Consequently, hypovitaminosis com­promises innate and adaptive immune responses, heightening susceptibility to infections and complications. COVID-19 vaccines primarily target SARS-CoV-2 Spike proteins, thus offering only a limited protection through antibodies. mRNA vaccines, such as those for COVID-19, fail to generate secretory/mucosal immunity-like IgG responses, rendering them ineffective in halting viral spread. Additionally, mutations in the SARS-CoV-2 binding domain reduce immune recog­nition by vaccine-derived antibodies, leading to immune evasion by mutant viruses like Omicron variants. Meanwhile, the repeated administration of bivalent boosters intended to enhance effi­cacy resulted in the immunoparesis of recipients. As a result, relying solely on vaccines for outbreak prevention, it became less effective. Dominant variants exhibit increased affinity to angiotensin-converting enzyme receptor-2, enhancing infectivity but reducing virulence. Mean­while, spike protein-related viral mutations do not impact the potency of widely available, repurposed early therapies, like vitamin D and ivermectin. With the re-emergence of COVID-19 and impending coronaviral pandemics, regulators and health organizations should proactively consider approval and strategic use of cost-effective adjunct therapies mentioned above to counter the loss of vaccine efficacy against emerging variants and novel coronaviruses and eliminate vaccine- and anti-viral agents-related serious adverse effects. Timely implementation of these strategies could reduce morbidity, mortality, and healthcare costs and provide a rational approach to address future epidemics and pandemics. This perspective critically reviews relevant literature, providing insights, justifications, and viewpoints into how the scientific community and health authorities can leverage this knowledge cost-effectively.
 Download the PDF from VitaminDWiki

Conclusions

The original COVID-19 vaccines effectively reduced hospitalizations but faced major challenges during winter outbreaks, leading to increased hospitalizations and mortality. Adequate vitamin D is critical for most human immune functions, including post-vaccination adaptive immunity. Individuals with low 25(OH)D concentrations have compromised immune systems and have less robust immune responses after vaccination, increasing their susceptibility to infections. Besides, COVID-19 mRNA vaccines predominantly target SARS-CoV-2 Spike proteins, providing limited antibody protection.
Moreover, mRNA-based COVID-19 vaccines provide no mucosal immunity, thus failing to prevent virus transmission. Additionally, mutations in the receptor binding regions of the SARS-CoV-2 viruses allow Omicron mutants to evade immune detection by antibodies. Besides, repeated bivalent vaccine boosters weaken the immune system and increase vulnerability to infection and re-infection. Consequently, exclusive reliance on COVID-19 vaccines to control outbreaks became ineffective. In contrast, Spike protein muta­tions do not impact the efficacy of repurposed, already approved generic, widely available early therapies like vitamin D and iver­mectin, thus remain effective. Regulators should consider approving them as cost-effective adjunct therapies, and health organizations should make them available to address emerging variants and enhance vaccine efficacy in future epidemics and pandemics. Timely implementation of the actions mentioned above has the potential to reduce morbidity, mortality, and healthcare costs, providing a rational, cost-effective approach without serious adverse effects of medications for future outbreaks and pandemics.

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VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos

As of March 31, 2024, the VitaminDWiki COVID page had:  trial results,   meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   All 26 COVID risk factors are associated with low Vit D,   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   166 COVID Clinical Trials using Vitamin D (Aug 2023)   Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
5 most-recently changed Virus entries

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A few other items by Sunil Wimalawansa

• Many diseases prevented if Vitamin D level higher than 50 ng -Sunil June 2024
• Many Chronic Health Diseases and Infections can controlled by 40 ng of Vitamin D – Aug 2023
• Physiological Basis for Using Vitamin D to Improve Health - May 2023
• Fight infections such as COVID with 50 ng of Vitamin D – Sunil Dec 2022
• Vitamin D: Bolus is Bogus (if more than 17 days between oral doses) – Oct 2021
• Coronavirus: How Bad Is It - Wimalawansa Feb 9 2020

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VitaminDWiki - Vitamin D can inhibit enveloped virus (e.g. Corona, Herpes, Bird Flu, Epstein, Hepatitis, RSV, etc.) – March 2011

Examples of enveloped virus   Coronavirus, Herpes simplex (cold sore), Shingles, Epstein-Barr, Hepatitis A & B & C, Zika, HIV, Dengue, Yellow fever, Measles, Mumps, smallpox, monkeypox, ebola, rabies, influenza A & B, West Nile, Valley Fever, Croup, Lasa Fever, Hemorrhagic Fever, H5N1 bird flu

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VitaminDWiki – Flu contains

Vitamin D fights all phases of Influenza

• FACT: Vitamin D PREVENTS Influenza 7X lower risk
• FACT: Vitamin D SUPRESSES Influenza ( Vitamin D Hammer )
  • Single dose of 50,000 IU of vitamin D stops Influenza symptoms
• FACT: Vitamin D PREVENTS & SUPRESSES Sepsis which is a rare but deadly consequence of Influenza
• FACT: Vitamin D enhances the activity of vaccines.
• FACT: improves Flu vaccine effectiveness and reduces side effects
• FACT: Vitamin D has virtually no side effects
  • but 1 in 300 get people get muscle pain or itching due to lower magnesium levels
• FACT: Vitamin D prevents/suppresses over 120 health problems (left column)
• FACT: Both COVID-19 and Influenza are enveloped viruses
  • Vitamin D can inhibit enveloped virus (e.g. Corona, Herpes, Bird Flu, Epstein, Hepatitis, RSV, etc.) – March 2011
• FACT: Do not take vitamin D if Sarcoidosis, excess Calcium, Chemotherapy
• CONCLUSION To help protect/suppress influenza, take 50,000 IU of Vitamin D once a week
     during the flu season if you are an average weight adult

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VitaminDWiki – Monkeypox - many items in 2022

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VitaminDWiki – Bird flu possible pandemic - many studies

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VitaminDWiki – Respiratory viral infection (RSV) and low vitamin D - many studies

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VitaminDWiki – Loading Dose of Vitamin D category contains:

206 items in category
see also Overview Loading of vitamin D   Overview Toxicity of vitamin D
Better than Daily 1: Fewer chances to forget, 2) Gets past receptor barrier
Injection category has 63 items
 
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of serious adverse reactions
Many studies report on the benefits resulting from loading doses

TOP articles in Loading Dose of Vitamin D

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FLCCC EARLY COVID Vitamin D loading doses (Sunil)

FLCCC = Front Line COVID-19 Critical Care Alliance
Table 3. A Single-Dose Regimen of Calcifediol to Rapidly Raise Serum 25(OH)D above 50 ng/mL

Body Weight   (lbs)	Body Weight   (kgs)	Calcifediol   (mg)	Equivalent in IU	If Calcifediol is not available a bolus of Vitamin D3
15-21	7-10	0.1	16,000	20,000
22-30	10-14	0.15	24,000	35,000
31-40	15-18	0.2	32,000	50,000
41-50	19-23	0.3	48,000	60,000
61-70	28-32	0.5	80,000	100,000
71-86	33-39	0.6	96,000	150,000
86-100	40-45	0.7	112,000	200,000
101-150	46-68	0.8	128,000	250,000
151-200	69-90	1.0	160,000	300,000
201-300	91-136	1.15	240,000	400,000
>300	>137	2.0	320,000	500,000

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VitaminDWiki – Immunity category contains

271 items in Immunity category

    see also

Virus category listing has 1388 items along with related searches

Overview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
228 VitaminDWiki pages contained "infection" in title (June 2024)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021
   Only the brain is more complex, nothing about Vitamin D
18 titles in VitaminDWiki contained INNATE or ADAPTIVE as of Jan 2023
Increasing publications on vitamin D and Infection

52 studies are in both Immunity and Virus categories

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VitaminDWiki - 52 studies in both categories of Immunity and Virus

This list is automatically updated